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Species InformationThe Methanosarcina acetivorans C2A genome is 5.75 Million bp long and contains approximately 4721 predicted genes. M. acetivorans is the largest known archaeal genome. Only Methanosarcina species possess all three known pathways for methanogenesis and are capable of utilizing no less than nine methanogenic substrates, including acetate. In contrast, all other orders of methanogens possess a single pathway for methanogenesis, and many utilize no more than two substrates.
Taxonomy: Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Sequencing: The sequence was released April 2002 by the Broad Institute, and was described in Genome Res 12:532-42 (2002) Galagan JE, Nusbaum C, Roy A, Endrizzi MG, Macdonald P, et al.."The genome of M. acetivorans reveals extensive metabolic and physiological diversity." Abstract: Methanogenesis, the biological production of methane, plays a pivotal role in the global carbon cycle and contributes significantly to global warming. The majority of methane in nature is derived from acetate. Here we report the complete genome sequence of an acetate-utilizing methanogen, Methanosarcina acetivorans C2A. Methanosarcineae are the most metabolically diverse methanogens, thrive in a broad range of environments, and are unique among the Archaea in forming complex... [Click above reference link for full abstract] Isolation: Appl Environ Microbiol 47:971-978 (1984) Sowers KR, Baron SF, Ferry JG, "Methanosarcina acetivorans sp. nov., an Acetotrophic Methane-Producing Bacterium Isolated from Marine Sediments." Abstract: A new acetotrophic marine methane-producing bacterium that was isolated from the methane-evolving sediments of a marine canyon is described. Exponential phase cultures grown with sodium acetate contained irregularly shaped cocci that aggregated in the early stationary phase and finally differentiated into communal cysts that released individual cocci when ruptured or transferred to fresh medium. The irregularly shaped cocci (1.9 +/- 0.2 mm in diameter) were gram negative and occurred... [Click above reference link for full abstract] Sequenced related species/strains: Methanosarcina barkeri str. Fusaro, Methanococcoides burtonii DSM 6242, Methanosarcina mazei Go1, Methanosaeta thermophila PT | Browse Specific Gene/Feature Sets |
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Sample position queriesA genome position can be specified by chromosomal coordinate range, COGID, or keywords from the GenBank or TIGR description of a gene. The available chromosome/plasmid names are:
| Browser Chrom/Plasmid Name | Length (bp) | GC Content (%) | Gene Count | NCBI RefSeq Accession |
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| chr | 5751492 | 42.68 | 4721 | NC_003552 |
The following list shows examples of valid position queries for thisgenome: | Request: | Genome Browser Response: |
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| chr | Displays the entire sequence "chr" in the browser window | | chr:1-10000 | Displays first ten thousand bases of the sequence "chr" | | transporter | Lists all genes with "transporter" in the name or description | | MA0010 | Display genome at position of gene MA0010 |
Phylogenetic tree of related species based on multiple-genome alignment in browser:
CreditsThe Archaeal Genome Browsers at UCSC were developed by members of theLowe Lab (Kevin Schneider,Katherine Pollard, Andy Pohl, Todd Lowe) and Robert Baertsch, with significant support fromthe UCSC Human GenomeBrowser group.The Archaeal Browsers are run by a slightly modifiedversion of the UCSC Human GenomeBrowser system. All queries, bug reports, content corrections, suggested improvements,and new track data submissions should be sent to Todd Lowe (lowe@soe.ucsc.edu).If you use the browser in your published research, please cite ourpublication in the Nucleic Acids Research DatabaseIssue. Citations and positive feedback will help us obtain fundingto continue development of this community resource.
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